Insulin-like growth factor-I: compartmentalization within the somatotropic axis?
نویسندگان
چکیده
Insulin-like growth factor-I (IGF-I) is essential for normal growth; igf-1 gene mutations are associated with extreme growth retardation in mice and, very rarely, in humans. The relative contributions of tissue vs. endocrine (hepatic) IGF-I to the regulation of growth has been a fundamental question. New gene targeting technologies are providing answers for these questions.
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عنوان ژورنال:
- News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society
دوره 17 شماره
صفحات -
تاریخ انتشار 2002